USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: TBB1_HUMAN USC-OGP 2-DE database:  TBB1_HUMAN TBB1_HUMAN General information about the entry View entry in simple text format Entry name TBB1_HUMAN Primary accession number P07437 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Tubulin beta chain; AltName: Full=Tubulin beta-5 chain;. Gene name Name=TUBB Synonyms=TUBB5 ORFNames=OK/SW-cl.56 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0058: pI=4.87; Mw=53960 SPOT OGP-0067: pI=4.86; Mw=51629 SPOT OGP-0071: pI=4.92; Mw=50950 SPOT OGP-0110: pI=5.03; Mw=38122 SPOT OGP-0183: pI=4.59; Mw=26413 SPOT OGP-0193: pI=4.66; Mw=25286 SPOT OGP-0205: pI=4.57; Mw=23744 SPOT OGP-0218: pI=4.91; Mw=21047 SPOT OGP-0251: pI=4.74; Mw=16408 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1210: pI=5.74; Mw=37929 Cross-references UniProtKB/Swiss-Prot P07437; TBB5_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TBB5_HUMAN Primary accession number P07437 Secondary accession number(s) P05218 Q8WUC1 Q9CY33 Sequence was last modified on  December 21, 2004 (version 2) Annotations were last modified on  March 15, 2017 (version 201) Name and origin of the protein Description RecName: Full=Tubulin beta chain; AltName: Full=Tubulin beta-5 chain; Gene name Name=TUBB Synonyms=TUBB5 ORFNames=OK/SW-cl.56 Encoded on Name=TUBB; Synonyms=TUBB5; ORFNames=OK/SW-cl.56 Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; GTP-binding; Isopeptide bond; Methylation; Microtubule; Nucleotide-binding; Phosphoprotein; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J00314; AAB59507.1; -; Genomic_DNA EMBL AF141349; AAD33873.1; -; mRNA EMBL AF070561; AAC28642.1; -; mRNA EMBL AF070593; AAC28650.1; -; mRNA EMBL AF070600; AAC28654.1; -; mRNA EMBL BA000025; BAB63321.1; -; Genomic_DNA EMBL AB088100; BAC54932.1; -; Genomic_DNA EMBL AB062393; BAB93480.1; -; mRNA EMBL BC001938; AAH01938.1; -; mRNA EMBL BC002347; AAH02347.1; -; mRNA EMBL BC005838; AAH05838.1; -; mRNA EMBL BC007605; AAH07605.1; -; mRNA EMBL BC013374; AAH13374.1; -; mRNA EMBL BC019924; AAH19924.1; -; mRNA EMBL BC020946; AAH20946.1; -; mRNA EMBL BC021909; AAH21909.1; -; mRNA EMBL BC070326; AAH70326.1; -; mRNA CCDS CCDS4687.1; -; . PIR A26561; A26561; . RefSeq NP_001280141.1; NM_001293212.1; . RefSeq NP_001280142.1; NM_001293213.1; . RefSeq NP_001280143.1; NM_001293214.1; . RefSeq NP_001280144.1; NM_001293215.1; . RefSeq NP_001280145.1; NM_001293216.1; . RefSeq NP_821133.1; NM_178014.3; . UniGene Hs.636480; -; . PDB 3QNZ; X-ray; 2.20 A; C=429-438 PDB 3QO0; X-ray; 2.30 A; C=422-441 PDBsum 3QNZ; -; . PDBsum 3QO0; -; . ProteinModelPortal P07437; -; . SMR P07437; -; . BioGrid 128444; 253; . DIP DIP-32772N; -; . IntAct P07437; 104; . MINT MINT-1146393; -; . STRING 9606.ENSP00000339001; -; . ChEMBL CHEMBL5444; -; . DrugBank DB05284; CA4P; . DrugBank DB01394; Colchicine; . DrugBank DB05147; CYT997; . DrugBank DB03010; Epothilone B; . DrugBank DB01873; Epothilone D; . DrugBank DB01179; Podofilox; . DrugBank DB00570; Vinblastine; . DrugBank DB00541; Vincristine; . DrugBank DB00361; Vinorelbine; . DrugBank DB06042; ZEN-012; . GuidetoPHARMACOLOGY 2640; -; . iPTMnet P07437; -; . PhosphoSitePlus P07437; -; . SwissPalm P07437; -; . BioMuta TUBB; -; . DMDM 56757569; -; . OGP P07437; -; . REPRODUCTION-2DPAGE P07437; -; . SWISS-2DPAGE P07437; -; . UCD-2DPAGE P07437; -; . EPD P07437; -; . PaxDb P07437; -; . PeptideAtlas P07437; -; . PRIDE P07437; -; . TopDownProteomics P07437; -; . Ensembl ENST00000327892; ENSP00000339001; ENSG00000196230; . Ensembl ENST00000383564; ENSP00000373058; ENSG00000183311; . Ensembl ENST00000419792; ENSP00000401317; ENSG00000235067; . Ensembl ENST00000421473; ENSP00000399155; ENSG00000224156; . Ensembl ENST00000422650; ENSP00000400663; ENSG00000229684; . Ensembl ENST00000422674; ENSP00000406811; ENSG00000227739; . Ensembl ENST00000432462; ENSP00000410829; ENSG00000232421; . Ensembl ENST00000436628; ENSP00000410071; ENSG00000232575; . GeneID 203068; -; . KEGG hsa:203068; -; . CTD 203068; -; . DisGeNET 203068; -; . GeneCards TUBB; -; . HGNC HGNC:20778; TUBB; . HPA CAB005417; -; . HPA CAB012406; -; . HPA HPA043640; -; . HPA HPA046280; -; . MalaCards TUBB; -; . MIM 156610; phenotype; . MIM 191130; gene; . MIM 615771; phenotype; . neXtProt NX_P07437; -; . OpenTargets ENSG00000196230; -; . PharmGKB PA358; -; . eggNOG KOG1375; Eukaryota; . eggNOG COG5023; LUCA; . GeneTree ENSGT00760000119061; -; . HOVERGEN HBG000089; -; . InParanoid P07437; -; . KO K07375; -; . OMA ESEKMRE; -; . OrthoDB EOG09370T84; -; . PhylomeDB P07437; -; . TreeFam TF300298; -; . Reactome R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; . Reactome R-HSA-380259; Loss of Nlp from mitotic centrosomes; . Reactome R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; . Reactome R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; . Reactome R-HSA-5620912; Anchoring of the basal body to the plasma membrane; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-8854518; AURKA Activation by TPX2; . SIGNOR P07437; -; . ChiTaRS TUBB; human; . GeneWiki TUBB; -; . GenomeRNAi 203068; -; . PRO PR:P07437; -; . Proteomes UP000005640; Chromosome 6; . Bgee ENSG00000183311; -; . CleanEx HS_TUBB; -; . ExpressionAtlas P07437; baseline and differential; . Genevisible P07437; HS; . GO GO:0035578; C:azurophil granule lumen; TAS:Reactome; . GO GO:0044297; C:cell body; IDA:DFLAT; . GO GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL; . GO GO:0005856; C:cytoskeleton; TAS:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005874; C:microtubule; IDA:UniProtKB; . GO GO:0015630; C:microtubule cytoskeleton; IDA:HPA; . GO GO:0005641; C:nuclear envelope lumen; IDA:DFLAT; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0043234; C:protein complex; IEA:Ensembl; . GO GO:0005525; F:GTP binding; IEA:UniProtKB-KW; . GO GO:0003924; F:GTPase activity; IEA:InterPro; . GO GO:0042288; F:MHC class I protein binding; IDA:UniProtKB; . GO GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl; . GO GO:0005198; F:structural molecule activity; TAS:BHF-UCL; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; . GO GO:0051301; P:cell division; TAS:BHF-UCL; . GO GO:0009987; P:cellular process; IDA:DFLAT; . GO GO:0097711; P:ciliary basal body docking; TAS:Reactome; . GO GO:0030705; P:cytoskeleton-dependent intracellular transport; TAS:BHF-UCL; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0007017; P:microtubule-based process; TAS:BHF-UCL; . GO GO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; . GO GO:0042267; P:natural killer cell mediated cytotoxicity; NAS:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0051225; P:spindle assembly; IEA:Ensembl; . Gene3D 1.10.287.600; -; 1; . Gene3D 3.30.1330.20; -; 1; . Gene3D 3.40.50.1440; -; 1; . InterPro IPR013838; Beta-tubulin_BS; . InterPro IPR002453; Beta_tubulin; . InterPro IPR008280; Tub_FtsZ_C; . InterPro IPR000217; Tubulin; . InterPro IPR018316; Tubulin/FtsZ_2-layer-sand-dom; . InterPro IPR023123; Tubulin_C; . InterPro IPR017975; Tubulin_CS; . InterPro IPR003008; Tubulin_FtsZ_GTPase; . PANTHER PTHR11588; PTHR11588; 1; . Pfam PF00091; Tubulin; 1; . Pfam PF03953; Tubulin_C; 1; . PRINTS PR01163; BETATUBULIN; . PRINTS PR01161; TUBULIN; . SMART SM00864; Tubulin; 1; . SMART SM00865; Tubulin_C; 1; . SUPFAM SSF52490; SSF52490; 1; . SUPFAM SSF55307; SSF55307; 1; . PROSITE PS00227; TUBULIN; 1; . PROSITE PS00228; TUBULIN_B_AUTOREG; 1; .

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